Caging and Uncaging Genetics
نویسندگان
چکیده
منابع مشابه
Caging and Uncaging Genetics
It is important for biology to understand if observations made in highly reductionist laboratory settings generalise to harsh and noisy natural environments in which genetic variation is sorted to produce adaptation. But what do we learn by studying, in the laboratory, a genetically diverse population that mirrors the wild? What is the best design for studying genetic variation? When should we ...
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This paper digs into the relationship between cages and grasps of a rigid body. In particular, it considers the use of cages as waypoints to grasp an object. We introduce the concept of pregrasping cages, caging configurations from which an object can be grasped without first breaking the cage. For two-fingered manipulators, all cages are pregrasping cages and, consequently, useful waypoints to...
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H ow do proteins fold spontaneously? The quest to answer this question has led to significant developments on theoretical, experimental, and computational fronts in the last decade (1–7). A combination of approaches has provided a detailed understanding of the nature of pathways and the transition states that the polypeptide chain encounters as it traverses the rugged energy landscape. Even as ...
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and the end conditions bx(0, t) = bx(`, t) = cx(0, t) = cx(`, t) = 0. Our task is to recover p ≡ {Db, Dc, k−, r, u} from knowledge of b(xj , ·) and Kd = k−/k+. Let us explicitly track the dependence of of b upon p by writing b = b(x, t; p) and write the IBVP above as R([b, c], p) = 0. Now differentiating R([b(p), c(p)], p) = 0 wrt p reveals ∂[b,c]R∂p[b, c] + ∂pR = 0 or ∂p[b(p), c(p)] = −∂[b,c]R...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2016
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1002525